Research Labs

Arun Srivastava Lab

Dr. Srivastava’s research has been focused on the following two parvoviruses, the non-pathogenic adeno-associated virus (AAV), and a common human pathogen, the parvovirus B19, and the development of recombinant parvovirus vectors in human gene therapy.

Brad Hoffman Lab

Dr. Hoffman is an Associate Professor and cellular immunologist with a major interest in immune modulation and tolerance induction using adeno-associated virus (AAV) gene therapy. Dr. Hoffman earned his Ph.D. in Immunology from Temple University School of Medicine in 2006. He subsequently performed postdoctoral research in gene therapy at University of Florida.

Sergei Zolotukhin Lab

The primary mission is to merge molecular genetics research and health care by developing new therapeutic strategies involving gene transfer. The idea of gene therapy is a logical and natural progression of the last 20 years of research in medical genetics and molecular biology.

Grant Support

Principal Investigator Sponsor Title
Arun Srivastava, PhD (Contact PI) National Institutes of Health, or NIH Next generation of recombinant AAV serotype vectors for gene therapy
Arun Srivastava, PhD NIH AAV2 and hepatocellular carcinoma
Arun Srivastava, PhD (Contact PI) NIH Mechanism of high-efficiency transduction of hepatocytes by optimized AAV vectors
Arun Srivastava, PhD Kitzman Endowment Research endowment
Arun Srivastava, PhD aaVective, Inc. Development of clinical candidate NextGen optimized AAV3B serotype vectors for gene therapy of hemophilia B and hemophilia A
Brad Hoffman, PhD NIH National Institute of Allergy and Infectious Diseases Restoring immune tolerance in a model of multiple sclerosis
Brad Hoffman, PhD (Co-PI) NIH National Institute of Neurological Disorders and Stroke Immune modulation and CNS pathology following exogenous alpha synuclein challenge
Brad Hoffman, PhD (Co-PI) NIH National Eye Institute Engineering AAV for safe and efficient gene delivery to the human retina
Brad Hoffman, PhD Sarepta Therapeutics Development of mouse models for clinical relevance
Brad Hoffman, PhD Sarepta Therapeutics Vector engineering and production
Brad Hoffman, PhD Sarepta Therapeutics Determine synergism of current disease modifying therapies
Brad Hoffman, PhD Sarepta Therapeutics Treg depletion studies in DTR mice