Geoffrey D Keeler,
Research Assistant Professor
Department:
MD-PEDS-CELL / MOLEC THERP DIV
Business Phone:
(352) 273-8258
Business Email:
gkeeler@ufl.edu
Teaching Profile
Courses Taught
2020-2022,2024
GMS6253 Molecular Therapy III – Immunology of Gene Transfer
2024
GMS6252 Molecular Therapy II – Disease Targets and Applications
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-1517-8894
Publications
2024
Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo.
Molecular therapy. Nucleic acids.
35(2)
[DOI] 10.1016/j.omtn.2024.102196.
[PMID] 38766527.
2024
Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy
Cellular Immunology.
397-398
[DOI] 10.1016/j.cellimm.2024.104806.
2023
Development of capsid- and genome-modified optimized AAVrh74 vectors for muscle gene therapy.
Molecular therapy. Methods & clinical development.
31
[DOI] 10.1016/j.omtm.2023.101147.
[PMID] 38046199.
2023
Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background.
Molecular therapy. Methods & clinical development.
28:177-189
[DOI] 10.1016/j.omtm.2022.12.011.
[PMID] 36700122.
2023
Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting
Viruses.
15(11)
[DOI] 10.3390/v15112168.
[PMID] 38005848.
2021
AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo.
Gene therapy.
28(7-8):422-434
[DOI] 10.1038/s41434-020-0140-1.
[PMID] 32152434.
2020
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing.
Molecular therapy. Nucleic acids.
20:451-458
[DOI] 10.1016/j.omtn.2020.03.009.
[PMID] 32276210.
2020
Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells.
Molecular therapy : the journal of the American Society of Gene Therapy.
28(3):758-770
[DOI] 10.1016/j.ymthe.2019.11.011.
[PMID] 31780366.
2019
Liver induced transgene tolerance with AAV vectors.
Cellular immunology.
342
[DOI] 10.1016/j.cellimm.2017.12.002.
[PMID] 29576315.
2018
Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy.
26(1):173-183
[DOI] 10.1016/j.ymthe.2017.09.001.
[PMID] 28943274.
2016
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.
Molecular therapy : the journal of the American Society of Gene Therapy.
24(6):1042-1049
[DOI] 10.1038/mt.2016.61.
[PMID] 27019999.
2015
Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats.
Acta biomaterialia.
23:27-37
[DOI] 10.1016/j.actbio.2015.05.011.
[PMID] 25985913.
2015
Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations.
Acta biomaterialia.
12:11-20
[DOI] 10.1016/j.actbio.2014.10.022.
[PMID] 25449921.
2014
Comparison of microdialysis sampling perfusion fluid components on the foreign body reaction in rat subcutaneous tissue.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
57:60-7
[DOI] 10.1016/j.ejps.2013.11.005.
[PMID] 24239995.
Grants
Feb 2023
ACTIVE
Restoring Immune Tolerance in a Model of Multiple Sclerosis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2018
– Nov 2019
Identifying optimal CD8 Treg for CAR Treg Therapy
Role: Principal Investigator
Funding: AMERICAN SOCIETY OF GENE AND CELL THERAP
Contact Details
Phones:
- Business:
- (352) 273-8258
Emails:
- Business:
- gkeeler@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
P.O. Box 100296
Gainesville FL 32610